2,4-Dimethoxyphenyl isocyanate → HCID 67329039, compound

HRID 1677646Notes

Reaction equation

HRID 1677646 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:15]=[CH:14][CH:13]=[C:12]([Cl:16])[C:9]=2[C:10]#[N:11])=[CH:4][CH:3]=1.[CH3:17][O:18][C:19]1[CH:24]=[C:23]([O:25][CH3:26])[CH:22]=[CH:21][C:20]=1[N:27]=[C:28]=[O:29]>>[Cl:16][C:12]1[CH:13]=[CH:14][N:15]=[C:8]([C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:28]([NH:27][C:20]3[CH:21]=[CH:22][C:23]([O:25][CH3:26])=[CH:24][C:19]=3[O:18][CH3:17])=[O:29])=[CH:7][CH:6]=2)[C:9]=1[C:10]#[N:11]

Participants

3

Reactant 2

HCID 6016372,4-Dimethoxyphenyl isocyanateHCID 58380761HCID 58380761, compound

Product 1

HCID 67329039HCID 67329039, compound

Procedure

2-(4-Aminophenyl)-4-chloronicotinonitrile is reacted with 2,4-dimethoxyphenyl isocyanate under conditions similar to those described in Example 27. 1-[4-(4-Chloro-3-cyanopyrid-2-yl)phenyl]-3-(2,4-dimethoxyphenyl)urea is obtained in the form of a white solid, the characteristics of which are as follows:

Sources & evidence

ORD record
ord-11f471dc308d4d759b2c37a7290b7d96
Source dataset
uspto-grants-2011_08
Patent number
US08008322B2

Reaction notes

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