HCID 24889965, compound → HCID 24889966, compound

HRID 1677671Notes

Reaction equation

HRID 1677671 reaction equation
[CH:1]1([CH2:7][CH:8]([N:17]2[CH2:25][C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[C:18]2=[NH:26])[C:9]([NH:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(C1C=C(C[F:38])C=CC=1CBr)#N>>[CH:1]1([CH2:7][CH:8]([N:17]2[CH2:25][C:24]3[C:19](=[CH:20][C:21]([F:38])=[CH:22][CH:23]=3)[C:18]2=[NH:26])[C:9]([NH:11][C:12]2[S:13][CH:14]=[CH:15][N:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 24889965HCID 24889965, compoundHCID 66990206HCID 66990206, compound

Product 1

HCID 24889966HCID 24889966, compound

Procedure

The title compound was synthesized according to the method described in connection with Compound 11, except that 2-cyano-4-fluoromethylbenzyl bromide was used. 1H NMR (400 MHz, MeOH-d4) δ: 7.99 (dd, J=2.4, 8.0 Hz, 1H), 7.76-7.82 (m, 1H), 7.58-7.66 (m, 1H), 7.44 (d, J=0.6 Hz, 1H), 7.13 (d, J=0.6 Hz, 1H), 5.11-5.21 (m, 2H), 4.96 (d, J=20.0 Hz, 1H), 2.03-2.24 (m, 2H), 1.70-1.90 (m, 5H), 1.0-138 (m, 6H). [M+H] calc'd for C20H23FN4OS, 387. found, 387.

Sources & evidence

ORD record
ord-34a57b6349274554964e20784231cad6
Source dataset
uspto-grants-2011_08
Patent number
US08008332B2

Reaction notes

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