関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | 4-(Bromomethyl)benzenesulfonyl chloride | HCID 2734409 | — |
| 反応物 | Methylamine hydrochloride | HCID 6364545 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(Bromomethyl)-N-methylbenzenesulfonamide | HCID 10015645 | — |
反応手順
To a chilled (0° C.) stirred solution of 4-(bromomethyl)-benzenesulfonylchloride (3.0 g, 11 mmol) in DCM (100 mL) was added methylamine hydrochloride (1.2 g, 12 mmol). After 30 minutes, water (100 mL) was added. The organic layer was separated, washed with brine (30 mL), and dried over sodium sulfate and concentrated in vacuo to afford 4-bromomethyl-N-methyl-benzenesulfonamide.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08008327B2 |
|---|
| 出典データセット | uspto-grants-2011_08 |
|---|
| ORD ID | ord-cb5e702125644c1baa2830aef7bc2f58 |
|---|
| 出典メモ | uspto-grants-2011_08 |
|---|
