Sodium Hydroxide → HCID 58138764, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-({[1-(4-fluoro-phenyl)-1H-indazole-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester (430 mg, 1.0 mmol) in ethanol (15 mL) was added a 2 N solution of aqueous sodium hydroxide (3.0 mL, 6.0 mmol). The mixture was heated at 80° C. for 4 hours. The mixture was cooled and concentrated in vacuo to remove the ethanol and then added to a solution of 1 N aqueous HCl (30 mL). The white precipitate was collected by filtration and dried to afford the title compound as a white solid.

Provenance & Evidence