1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid → HCID 66917058, compound

HRID 1677697Notes

Reaction equation

HRID 1677697 reaction equation
C[O:2][C:3]([C:5]1[C:6]2[C:7]([Br:14])=[N:8][NH:9][C:10]=2[CH:11]=[CH:12][CH:13]=1)=[O:4].[F:15][C:16]1[CH:21]=[CH:20][C:19](N2C3C=CC=C(C(O)=O)C=3C=N2)=[CH:18][CH:17]=1>>[Br:14][C:7]1[C:6]2[C:5]([C:3]([OH:2])=[O:4])=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]([C:19]2[CH:20]=[CH:21][C:16]([F:15])=[CH:17][CH:18]=2)[N:8]=1

Participants

3

Reactant 2

HCID 581387741-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acidHCID 178497596HCID 178497596, compound

Product 1

HCID 66917058HCID 66917058, compound

Procedure

3-Bromo-1H-indazole-4-carboxylic acid methyl ester was then subjected to the reaction conditions described in Example 2, for the synthesis of 1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid, to yield 3-bromo-1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid. Using the methods described in Example 2,3-bromo-1-(4-fluoro-phenyl)-1H-indazole-4-carboxylic acid was used to provide the following compounds:

Sources & evidence

ORD record
ord-10ca8d89088a438cb1721469bc0a205f
Source dataset
uspto-grants-2011_08
Patent number
US08008327B2

Reaction notes

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