Hydrochloric Acid → HCID 86650869, compound

Participants

Reaction Steps

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(6-bromo-pyridin-3-yl)-propyl]-amide (5.35 g, 16.8 mmol) in methanol (25 mL) was added a solution of 4 N HCl in dioxane (10.0 mL, 40.0 mmol). The mixture was monitored by TLC for the disappearance of starting material (ethyl acetate-hexanes 3:7). After 2 hours, the mixture was concentrated to near dryness to afford a white solid which was diluted with diethylether and collected by filtration to afford (S)-1-(6-bromo-pyridin-3-yl)-propylamine hydrochloride.

Provenance & Evidence