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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1677740Generated: November 4, 2026

Isonicotinic Acid → 1-(Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-piperazine dihydrochloride

https://huagongshe.com/reaction/1677740

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIsonicotinic AcidHCID 5922—
Reactant1-(5-Phenyl-1,2,4-oxadiazol-3-yl)piperazine dihydrochlorideHCID 67333109—
Product1-(Pyridin-4-yl-[1,2,4]oxadiazol-3-yl)-piperazine dihydrochlorideHCID 67332880—

Reaction Steps

The title product was prepared following the procedure of Intermediate 11 (step a to d) but using isonicotinic acid in step c). The title compound was obtained as a solid. TLC—Chloroform/methanol (8/2): Rf=0.2. HPLC purity: 97%.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008302B2
Source datasetuspto-grants-2011_08
ORD IDord-0b4fc37deb5c49cc9361f2f17b196db1
Source noteuspto-grants-2011_08