2-Bromo-6-methoxynaphthalene → HCID 58488023, compound

HRID 1677746Notes

Reaction equation

HRID 1677746 reaction equation
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4](C2C=CC(CCC)=CC=2)[CH2:3]1.Br[C:18]1[CH:27]=[CH:26][C:25]2[C:20](=[CH:21][CH:22]=[C:23]([O:28][CH3:29])[CH:24]=2)[CH:19]=1>>[CH3:29][O:28][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[CH:19]=[C:18]([N:4]1[CH2:5][CH2:6][NH:7][C@H:2]([CH3:1])[CH2:3]1)[CH:27]=[CH:26]2

Participants

3

Reactant 2

HCID 787862-Bromo-6-methoxynaphthaleneHCID 58487948HCID 58487948, compound

Product 1

HCID 58488023HCID 58488023, compound

Procedure

The title compound was prepared following the procedure of Intermediate 17, but starting from 2-bromo-6-methoxynaphthalene. Purification by chromatography (DCM/MeOH 80/20) afforded the title compound as an off white solid (43%). HPLC (Condition A), Rt: 2.2 min (HPLC purity: 98.4%). M+(ESI): 257.2

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography (DCM/MeOH 80/20)

Sources & evidence

ORD record
ord-0c662857f7e943cc99d4f3673b3caca5
Source dataset
uspto-grants-2011_08
Patent number
US08008302B2

Reaction notes

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