1-bromo-4-propoxybenzene → HCID 58487967, compound

HRID 1677748Notes

Reaction equation

HRID 1677748 reaction equation
[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:13]=[CH:12][C:11](CCC)=[CH:10][CH:9]=2)[CH2:3]1.BrC1C=C[C:21]([O:24]CCC)=[CH:20][CH:19]=1>>[CH3:1][C@H:2]1[NH:7][CH2:6][CH2:5][N:4]([C:8]2[CH:9]=[CH:10][C:11]([O:24][CH2:21][CH2:20][CH3:19])=[CH:12][CH:13]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 27341981-bromo-4-propoxybenzeneHCID 58487948HCID 58487948, compound

Product 1

HCID 58487967HCID 58487967, compoundYield 34%

Procedure

The title compound was prepared following the procedure of Intermediate 17, but starting from 1-bromo-4-propoxybenzene. Purification by chromatography (DCM/MeOH 80/20) afforded the title compound as a brown oil (34%). HPLC (Condition A), Rt: 1.9 min (HPLC purity: 80.2%). M+(ESI): 235.2

Workup

  1. customThe title compound was prepared
  2. customPurification by chromatography (DCM/MeOH 80/20)

Sources & evidence

ORD record
ord-6de582d40f1b4da0a49ddc40180942fb
Source dataset
uspto-grants-2011_08
Patent number
US08008302B2

Reaction notes

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