5-Bromo-2,3-dihydro-1-benzofuran → (3R)-1-(2,3-dihydro-1-benzofuran-5-yl)-3-methylpiperazine

Participants

Role	Name	HCID	Charge
Reactant	5-Bromo-2,3-dihydro-1-benzofuran	HCID 2776159	—
Reactant	(3R)-1-(3,4-dimethoxyphenyl)-3-methylpiperazine	HCID 58487959	—
Product	(3R)-1-(2,3-dihydro-1-benzofuran-5-yl)-3-methylpiperazine	HCID 11651447	—

Reaction Steps

The title compound was prepared following the procedure of Intermediate 25, but starting from 5-bromo-2,3-dihydrobenzo[b]furan. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a brown oil. M+(ESI): 219.2. HPLC (Condition A), Rt: 1.3 min (HPLC purity: 99.9%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08008302B2
Source dataset	uspto-grants-2011_08
ORD ID	ord-18573d58d24a4d35b92ddcaed96c294a
Source note	uspto-grants-2011_08