HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromoanisole → (3R)-1-(4-methoxyphenyl)-3-methylpiperazine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | (3R)-1-(3,4-dimethoxyphenyl)-3-methylpiperazine | HCID 58487959 | — |
| Product | (3R)-1-(4-methoxyphenyl)-3-methylpiperazine | HCID 27441151 | — |
Reaction Steps
The title compound was prepared following the procedure of Intermediate 25, but starting from 1-bromo-4-methoxybenzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a yellow oil. M+(ESI): 207.2. HPLC (Condition A), Rt: 1.2 min (HPLC purity: 92.2%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008302B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-65e6cf038df142cfa21677c8d64b5055 |
| Source note | uspto-grants-2011_08 |