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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1677758Generated: October 31, 2026

4-Bromophenetole → (3R)-1-(4-ethoxyphenyl)-3-methylpiperazine

https://huagongshe.com/reaction/1677758

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromophenetoleHCID 68523—
ReactantHCID 58487952HCID 58487952—
Product(3R)-1-(4-ethoxyphenyl)-3-methylpiperazineHCID 58487956—

Reaction Steps

The title compound was prepared following the procedure of Intermediate 22 but starting from 1-bromo-4-ethoxybenzene. Purification by flash chromatography (CHCl3/MeOH) gave the title compound as a brown solid. M+(ESI): 221.3. HPLC (Condition A), Rt: 1.5 min (HPLC purity: 97.6%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08008302B2
Source datasetuspto-grants-2011_08
ORD IDord-6d75fbfc3cb04e19b76e83dcd067424d
Source noteuspto-grants-2011_08