Ammonium Hydroxide → 1H-Indole-2-carboxamide

Participants

Reaction Steps

Add to a solution of indole-2-carboxylic acid 3 (31.0 mmol) and anhydrous THF (50 ml), carbonyldiimidazole (1.10 equiv., 5.5 g, 34.0 mmol). Stir for 1 h and add conc. NH4OH (50 mL) in one portion to the thick suspension. Stir at rt and after 16 h collect the solid by filtration, wash with H2O and dry in vacuuo at 40° C. to afford the indole-2-carboxamide 4 (R2═R3═H).

Provenance & Evidence