反应详情

Stir ethyl indole-2-carboxylate 1 (X═H, 4.67 mmol) or methyl indole-2-carboxylate 2 (X═H, 4.67 mmol) in Me2NH/H2O (50 mL, 40%). Stir the reaction mixture at rt for 16 h monitoring by tlc (10% MeOH/CH2Cl2). Concentrate the mixture to minimum volume, dilute with H2O and collect the solid by filtration. Wash the filter cake with H2O and dry under vacuum at 60° C. to provide dimethyl amide 4 (X═H, R2═R3=Me), tlc Rf=0.65 (silica gel, 10% MeOH/CH2Cl2).

1. concentrationConcentrate the mixture to minimum volume
2. additiondilute with H2O
3. customcollect the solid
4. filtrationby filtration
5. washWash the filter cake with H2O
6. customdry under vacuum at 60° C.