5-Fluoroindole-2-carboxylic acid → HCID 9035231, compound

Participants

Reaction Steps

Treat 1H-indole-2-carboxylic acid 3 (X═H, 750 mg, 4.66 mmol) with piperidine (3.0 equiv., 1.4 mL, 13.98 mmol) as described in General Synthetic Procedure VIa to afford 1H-indol-2yl-piperidin-1-yl-methanone 8 (X═H, R4=piperidin-1-yl; 979 mg, 92%) as a white solid. Treat 1H-indol-2yl-piperidin-1-yl-methanone (116 mg, 0.51 mmol) with 2-aminophenyldisulfide (347 mg, 1.4 equiv.) as described in General Synthetic Procedure VIIa to afford the title compound Iab (103 mg, 29%) as a tan solid, m/z=352 (M+1).

Provenance & Evidence