反应详情

To a solution of lithium aluminum hydride (7.79 g, 195 mmol) in anhydrous diethyl ether (435 mL) was added slowly as a powder, via a solid dropping funnel, 3,4-dichlorophenyl acetic acid (27.20 g, 130 mmol). When the addition was completed, the reaction mixture was refluxed for 12 hours. The reaction was quenched by cautious addition of saturated sodium sulfate aqueous solution (20 mL), the resulting insoluble was then filtered off and the filtrate was concentrated in vacuo to yield 25.09 g of the desired alcohol.

1. additionWhen the addition
2. temperaturethe reaction mixture was refluxed for 12 hours
3. customThe reaction was quenched by cautious addition of saturated sodium sulfate aqueous solution (20 mL)
4. filtrationthe resulting insoluble was then filtered off
5. concentrationthe filtrate was concentrated in vacuo