Sodium Bicarbonate → 2-Methyl-5-(pentafluorosulfur)aniline

Participants

Reaction Steps

2.0 g of 1-dichloromethyl-2-nitro-4-pentafluorosulfanylbenzene were dissolved in 25 ml of DME and, after addition of 200 mg of Pd/C (5%) and 100 ml of a saturated aqueous NaHCO3 solution, hydrogenated under 5 bar of H2 for 54 hours. The catalyst was then removed by filtration and the reaction solution was extracted 3 times with 50 ml of MTB each time. Drying over MgSO4 was followed by removal of the solvent in vacuo. 1.1 g of a colorless oil were obtained.

Provenance & Evidence