HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2-fluorobenzene-1-sulfonyl chloride → 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2-fluorobenzene-1-sulfonyl chloride | HCID 2736310 | — |
| Catalyst | Iron chloride (FeCl3) | HCID 24380 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 4-Bromo-2-fluoro-1-(phenylsulfonyl)benzene | HCID 67374087 | — |
Reaction Steps
4-Bromo-2-fluoro-benzenesulfonyl chloride (2 g), benzene (1.3 ml) and iron (III) chloride (35 mg) were heated in a sealed tube using a microwave at 200 Watts for 15 seconds. After cooling purification by flash column chromatography (eluent 20% EtOAc/Hexane) gave the subtitle compound as a solid, yield 1.8 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008350B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-325941259cf94eb5b5d5ec1437bd99d7 |
| Source note | uspto-grants-2011_08 |