5-Chloro-2-methoxyphenylboronic acid → 5'-Chloro-2-fluoro-4-[(4-fluorophenyl)sulfonyl]-2'-methoxybiphenyl

HRID 1677876Notes

Reaction equation

HRID 1677876 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[CH:4][C:3]=1[F:18].[Cl:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24](B(O)O)[CH:25]=1>>[Cl:19][C:20]1[CH:25]=[CH:24][C:23]([O:29][CH3:30])=[C:22]([C:2]2[CH:7]=[CH:6][C:5]([S:8]([C:11]3[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=3)(=[O:10])=[O:9])=[CH:4][C:3]=2[F:18])[CH:21]=1

Participants

3

Reactant 2

HCID 27357515-Chloro-2-methoxyphenylboronic acidHCID 684345101-Bromo-2-fluoro-4-[(4-fluorophenyl)sulfonyl]benzene

Product 1

HCID 672408645'-Chloro-2-fluoro-4-[(4-fluorophenyl)sulfonyl]-2'-methoxybiphenyl

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (i) and 5-chloro-2-methoxybenzene boronic acid.

Sources & evidence

ORD record
ord-c2c8e4b66d064e57b3844cddd50e4a76
Source dataset
uspto-grants-2011_08
Patent number
US08008350B2

Reaction notes

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