HCID 67241477, compound → HCID 67239262, compound

HRID 1677881Notes

Reaction equation

HRID 1677881 reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][C:12]([F:15])=[CH:11][C:10]=1[C:16]1[CH:21]=[CH:20][C:19]([S:22]([C:25]2[CH:30]=[CH:29][C:28]([O:31][CH3:32])=[CH:27][CH:26]=2)(=[O:24])=[O:23])=[C:18]([F:33])[CH:17]=1)C1C=CC=CC=1.[H][H]>C(O)(=O)C.[Pd]>[F:33][C:18]1[CH:17]=[C:16]([C:10]2[C:9]([OH:8])=[CH:14][CH:13]=[C:12]([F:15])[CH:11]=2)[CH:21]=[CH:20][C:19]=1[S:22]([C:25]1[CH:26]=[CH:27][C:28]([O:31][CH3:32])=[CH:29][CH:30]=1)(=[O:23])=[O:24]

Participants

5

Reactant 2

HCID 67241477HCID 67241477, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 67239262HCID 67239262, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 176Acetic AcidSolvent

Procedure

A suspension of the product of step (ii) (838 mg) in acetic acid (30 ml) and 10% Pd/C (200 mg) was stirred under 2 bar pressure of hydrogen for 30 min. The catalyst was removed by filtration and the filtrate was evaporated to give the subtitle compound, yield 630 mg.

Workup

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-99c72bb51e154aaeaac2fe85e9c8fd82
Source dataset
uspto-grants-2011_08
Patent number
US08008350B2

Reaction notes

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