5-Fluoro-2-methoxyphenylboronic acid → 2-Chlorophenyl 3,5'-difluoro-2'-methoxybiphenyl-4-yl sulfone

HRID 1677890Notes

Reaction equation

HRID 1677890 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[Cl:17])(=[O:10])=[O:9])=[C:4]([F:18])[CH:3]=1.[F:19][C:20]1[CH:21]=[CH:22][C:23]([O:29][CH3:30])=[C:24](B(O)O)[CH:25]=1>>[F:18][C:4]1[CH:3]=[C:2]([C:22]2[CH:21]=[C:20]([F:19])[CH:25]=[CH:24][C:23]=2[O:29][CH3:30])[CH:7]=[CH:6][C:5]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17])(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 672403144-Bromo-1-[(2-chlorophenyl)sulfonyl]-2-fluorobenzene

Product 1

HCID 672423202-Chlorophenyl 3,5'-difluoro-2'-methoxybiphenyl-4-yl sulfone

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (ii) and 5-fluoro-2-methoxybenzene boronic acid which was used directly in step (iv) without further characterisation.

Sources & evidence

ORD record
ord-c3d01f82435f4483abb812353e0fd505
Source dataset
uspto-grants-2011_08
Patent number
US08008350B2

Reaction notes

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