Boron tribromide → 4'-[(2-Chlorophenyl)sulfonyl]-3',5-difluorobiphenyl-2-ol

HRID 1677891Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:18]2[CH:23]=[C:22]([F:24])[CH:21]=[CH:20][C:19]=2[O:25]C)[CH:5]=[CH:6][C:7]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=1[Cl:17])(=[O:10])=[O:9].B(Br)(Br)Br>>[Cl:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[S:8]([C:7]1[CH:6]=[CH:5][C:4]([C:18]2[C:19]([OH:25])=[CH:20][CH:21]=[C:22]([F:24])[CH:23]=2)=[CH:3][C:2]=1[F:1])(=[O:9])=[O:10]

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 672423202-Chlorophenyl 3,5'-difluoro-2'-methoxybiphenyl-4-yl sulfone

Product 1

HCID 672412524'-[(2-Chlorophenyl)sulfonyl]-3',5-difluorobiphenyl-2-ol

Procedure

The subtitle compound was prepared by the method of example 2 step (iii) using the product of step (iii) and boron tribromide.

Sources & evidence

ORD record: ord-6154218cb85849879b5923d7812d56be
Source dataset: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08008350B2

Reaction notes

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