5-Fluoro-2-methoxyphenylboronic acid → 3'-Chloro-5-fluoro-2-methoxy-4'-(phenylsulfonyl)biphenyl

HRID 1677893Notes

Reaction equation

HRID 1677893 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([S:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(=[O:10])=[O:9])=[C:4]([Cl:17])[CH:3]=1.[F:18][C:19]1[CH:20]=[CH:21][C:22]([O:28][CH3:29])=[C:23](B(O)O)[CH:24]=1>>[Cl:17][C:4]1[CH:3]=[C:2]([C:21]2[CH:20]=[C:19]([F:18])[CH:24]=[CH:23][C:22]=2[O:28][CH3:29])[CH:7]=[CH:6][C:5]=1[S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)(=[O:10])=[O:9]

Participants

3

Reactant 2

HCID 27826735-Fluoro-2-methoxyphenylboronic acidHCID 665825034-bromo-2-chloro-1-(phenylsulfonyl)Benzene

Product 1

HCID 672392873'-Chloro-5-fluoro-2-methoxy-4'-(phenylsulfonyl)biphenyl

Procedure

The subtitle compound was prepared by the method of example 2 step (ii) using the product of step (i) and 5-fluoro-2-methoxybenzene boronic acid.

Sources & evidence

ORD record
ord-8e4252a84a6a4c2981b6e8dea4db5785
Source dataset
uspto-grants-2011_08
Patent number
US08008350B2

Reaction notes

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