Pyridine → HCID 66798088, compound

Participants

Reaction Steps

To a solution of (1R,2R,4R)-4-({[tert-butyl(dimethyl)silyl]oxy}methyl)-2-({6-[(1S)-2,3-dihydro-1H-inden-1-ylamino]pyrimidin-4-yl}amino)cyclopentanol (0.193 g, 0.424 mmol), N,N-dimethylaminopyridine (4.7 mg, 0.039 mmol) and pyridine (0.281 mL, 3.48 mmol) in DCM (2.1 mL) was added acetic anhydride (0.044 mL, 0.46 mmol) and the mixture stirred overnight. The reaction was diluted with CH2CL2 (10 mL) and H2O (20 mL) then stirred for 10 m. The organic layer was separated and the aqueous layer was extracted with CH2CL2 and combined organics were washed with H2O. The organic layer was dried (MgSO4), filtered and concentrated in vacuo to obtain the title compound. LC/MS: Rt=1.74 min, ES+ 498 (FA Standard).

Provenance & Evidence