Triethylamine → HCID 58629120, compound

Participants

Reaction Steps

A stirred solution of 4-chloro-5-methoxythieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester (1.0 g, 3.8 mmol), 1-(4-methoxyphenyl)ethylamine (0.8 g, 5 mmol) and triethylamine (1 mL) in DMF (20 mL) was warmed to 60° C. for 1 hour. The reaction was diluted with water (50 mL) and extracted with ethyl acetate (2×50 mL). The combined organic phases were washed with brine, dried (Na2SO4), filtered and concentrated. The crude product was purified by chromatography over silica gel (25 percent EtOAc in hexanes) affording product as a powder (700 mg, 1.5 mmol).

Provenance & Evidence