HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → Methyl 5-hydroxypyridine-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 5-Hydroxypyridine-2-carboxylic acid | HCID 268740 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 5-hydroxypyridine-2-carboxylate | HCID 4715126 | — |
Reaction Steps
To 5-hydroxypyridine-2-carboxylic acid (5.0 g, 36 mmol) suspended in CH2Cl2 (120 mL) was added DMF (1 mL) followed by oxalyl chloride (4.7 g, 37 mmol). After 1 hour, excess MeOH was added. The resulting mixture was stripped of solvent in vacuo yielding a brown solid that was washed with hot EtOAc. Yielded 4.6 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008487B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-4162643f60614b36ae71fbd7196b5e74 |
| Source note | uspto-grants-2011_08 |