反应详情

A 3 M solution of MeMgBr in Et2O (7.2 mmol) was added to a stirred solution of 6-(trifluoromethyl)nicotinonitrile (0.82 g, 4.8 mmol) in ether (16 mL) dropwise over a 30 minute period. The reaction was stirred for 2 hours then the mixture was quenched with aqueous 1N HCl and extracted with Et2O. The organics were combined and washed with brine and dried over anhydrous MgSO4. The solvent was removed in vacuo yielding 530 mg of a brown solid.

1. customthe mixture was quenched with aqueous 1N HCl
2. extractionextracted with Et2O
3. washwashed with brine
4. dry with materialdried over anhydrous MgSO4
5. customThe solvent was removed in vacuo