反应详情

2.31 mmol (0.50 g) of 1-(4-chlorobutyl)-5-methylpyrimidine-2,4(1H,3H)-dione, 0.65 g (11.54 mmol) of KOH and 1.64 g (11.54 mmol) of methyl rodide in 20.5 ml of dimethyl sulfoxide (DMSO) were stirred at room temperature for 5 hours. Water was added to the reaction mixture, and the aqueous mixture was extracted three times with methyl tert-butyl ether. The combined organic phase was then washed three times with saturated aqueous brine, and the organic phase was dried, filtered to remove the desiccant and concentrated. 0.53 g of a pale cloudy oil was obtained.

1. extractionthe aqueous mixture was extracted three times with methyl tert-butyl ether
2. washThe combined organic phase was then washed three times with saturated aqueous brine
3. customthe organic phase was dried
4. filtrationfiltered
5. customto remove the desiccant and
6. concentrationconcentrated
7. custom0.53 g of a pale cloudy oil was obtained