Hydrochloric Acid → phosphoric acid diethyl ester 2-[4-(3-formyl-1-phenyl-1H-indol-2-yl)-piperazin-1-yl]-ethyl ester hydrochloride

Participants

Reaction Steps

Phosphoric acid diethyl ester 2-[4-(3-formyl-1-phenyl-1H-indol-2-yl)piperazin-1-yl]ethyl ester is treated with 1M ethereal hydrochloric acid as described in Step 2 of Example 31 to obtain phosphoric acid diethyl ester 2-[4-(3-formyl-1-phenyl-1H-indol-2-yl)-piperazin-1-yl]-ethyl ester hydrochloride (54% yield) as pink powder. ESI/MS 486 (M+H); RT=2.52 min: NMR 10.15 (1H, s); 8.13 (1H, d, J=6 Hz); 7.70 (5H, m); 7.24 (2H, m); 6.96 (1H, d, J=9 Hz); 4.30 (2H, br s); 4.07 (6H, m); 3.59 (8H, br m); 1.27 (6H, t).

Provenance & Evidence