Morpholine → HCID 59754748, compound

HRID 1678167Notes

Reaction equation

HRID 1678167 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1>>[N:19]1([C:2]2[N:3]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[C:4]3[C:9]([C:10]=2[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=3)[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 3147932-chloro-1-phenyl-1H-indole-3-carbaldehyde

Product 1

HCID 59754748HCID 59754748, compound

Procedure

2-Chloro-1-phenyl-1H-indole-3-carboxaldehyde is reacted with morpholine as described in Step 2 of Example 29 to afford 2-(morpholin-4-yl)-1-phenyl-1H-indole-3-carboxaldehyde (885 yield) as a fluffy, creamy solid. ESI/MS 307 (M+H); RT=2.99 min; NMR 10.15 (1H, s); 8.14 (1H, d, J=6 Hz); 7.69 (5H, m); 7.22 (2H, m); 6.94 (1H, d, J=9 Hz); 3.45 (4H, m); 3.28 (4H, m).

Sources & evidence

ORD record
ord-201cf1944c7a4a5792596c32fa16da00
Source dataset
uspto-grants-2011_08
Patent number
US08008491B2

Reaction notes

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