HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-chloro-1H-indole-3-carbaldehyde → 2-chloro-1-(4-methyl-3-nitrophenyl)-1H-indole-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-chloro-1H-indole-3-carbaldehyde | HCID 314791 | — |
| Reactant | 4-Methyl-3-nitrobenzeneboronic acid | HCID 2773515 | — |
| Product | 2-chloro-1-(4-methyl-3-nitrophenyl)-1H-indole-3-carboxaldehyde | HCID 86035915 | 35% |
Reaction Steps
2-Chloro-1H-indole-3-carboxaldehyde is reacted with 4-methyl-3-nitrophenylboronic acid as described in Step 1 of Example 29 to afford 2-chloro-1-(4-methyl-3-nitrophenyl)-1H-indole-3-carboxaldehyde (35% yield) as a light cream solid. ESI/MS 315 (M+H); 356 [(M+1+CH3CN) adduct]; RT=3.35 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008491B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-49926f27ee9d40248546cc3e23ad3f4f |
| Source note | uspto-grants-2011_08 |