HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazine → 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazine | HCID 4837 | — |
| Reactant | 2-chloro-1-(4-methylphenyl)-1H-indole-3-carboxaldehyde | HCID 86035929 | — |
| Product | 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde | HCID 11438571 | 29% |
Reaction Steps
2-chloro-1-(4-methylphenyl)-1H-indole-3-carboxaldehyde is reacted with piperazine as described in Step 2 of Example 29 to afford 1-(4-methylphenyl)-2-(piperazin-1-yl)-1H-indole-3-carboxaldehyde (29% yield). ESI/MS 320 (M+H); RT=2.64 min; NMR (CDCl3) 10.27 (1H, s); 8.27 (1H, d, J=9 Hz); 7.38-7.15 (6H, m); 6.96 (1H, d, J=6 Hz); 3.26 (4H, m); 2.81 (4H, m); 2.47 (3H, s).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008491B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-a9bc27ba653344b0a26734cbdd147700 |
| Source note | uspto-grants-2011_08 |