化工社化工社 化学情報印刷レポート · 研究参考用
4-Fluorophenylboronic acid → 2-chloro-1-(4-fluorophenyl)-1H-indole-3-carboxaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Fluorophenylboronic acid | HCID 285645 | — |
| 反応物 | 2-chloro-1H-indole-3-carbaldehyde | HCID 314791 | — |
| 生成物 | 2-chloro-1-(4-fluorophenyl)-1H-indole-3-carboxaldehyde | HCID 86035933 | 84% |
反応手順
2-Chloro-1H-indole-3-carboxaldehyde is reacted with 4-fluorophenylboronic acid as described in Step 1 of Example 29 to afford 2-chloro-1-(4-fluorophenyl)-1H-indole-3-carboxaldehyde (84% yield) as a cream solid. ESI/MS 274 (M+H); RT=3.64 min; NMR 10.12 (1H, s); 8.20 (1H, d, J=6 Hz); 7.72 (2H, m); 7.58 (2H, m); 7.39 (2H, m); 7.12(1H, d, J=9 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08008491B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-b5b51a107bb74352b2e849173687b01d |
| 出典メモ | uspto-grants-2011_08 |