2-chloro-1H-indole-3-carbaldehyde → HCID 86035942, compound

HRID 1678192Notes

Reaction equation

HRID 1678192 reaction equation
[Cl:1][C:2]1[NH:3][C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2.[CH2:13]([O:15][C:16]1[CH:21]=[CH:20][C:19](B(O)O)=[CH:18][CH:17]=1)[CH3:14]>>[Cl:1][C:2]1[N:3]([C:19]2[CH:20]=[CH:21][C:16]([O:15][CH2:13][CH3:14])=[CH:17][CH:18]=2)[C:4]2[C:9]([C:10]=1[CH:11]=[O:12])=[CH:8][CH:7]=[CH:6][CH:5]=2

Participants

3

Reactant 2

HCID 3147912-chloro-1H-indole-3-carbaldehydeHCID 27343514-Ethoxyphenylboronic acid

Product 1

HCID 86035942HCID 86035942, compoundYield 37%

Procedure

2-Chloro-1H-indole-3-carboxaldehyde is reacted with 4-ethoxyphenylboronic acid as described in Step 1 of Example 29 to afford 2-chloro-1-(4-ethoxyphenyl)-1H-indole-3-carboxaldehyde (37% yield) as a off white solid. ESI/MS 300 (M+H); RT=3.56 min.

Sources & evidence

ORD record
ord-09ce9a16c2d84657a2da2ce9bd0a000c
Source dataset
uspto-grants-2011_08
Patent number
US08008491B2

Reaction notes

Loading…