Dimethylformamide dimethyl acetal → HCID 10923381, compound

Participants

Reaction Conditions

Reaction Steps

4-Methyl-5-nitro-pyridin-2-ylamine (Aldrich, 4.80 g, 31.4 mmol) was suspended in dimethoxymethyl-dimethylamine (50 mL) and the mixture was heated at about 120° C. in a sealed vessel with stirring for about 4 days. The reaction was cooled and concentrated to afford N′-[4-((E)-2-Dimethylamino-vinyl)-5-nitro-pyridin-2-yl]-N,N-dimethyl-formamidine (8.36 g, 101%) as a dark solid, RP HPLC (Table 1, Method e) Rt=1.62, m/z: (MH)+ 264. The crude product was then used in the next step without further purification.

Provenance & Evidence