HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 4-Amino-7-(trifluoromethyl)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | 4-Chloro-7-(trifluoromethyl)quinoline | HCID 67668 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Amino-7-(trifluoromethyl)quinoline | HCID 2735960 | — |
Reaction Steps
A solution of 4-chloro-7-trifluoromethylquinoline (1 g) and ammonium chloride (1 g) in methanol (10 mL) was heated at 70° C. overnight. Then the solid was filtered off and washed with methanol. The filtrated was evaporated to give 4-amino-7-trifluoromethylquinoline. LCMS: ret. time: 14.81 min.; purity: 82.25%; MS (m/e): 228.11 (M+16).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008501B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-2299b1780c344cf68e6af34e073ce4f6 |
| Source note | uspto-grants-2011_08 |