1-(4-Chloro-3-(trifluoromethyl)phenyl)piperazine → 9-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide

HRID 167837Notes

Reaction equation

HRID 167837 reaction equation
[Cl:1][c:2]1[c:3]([C:14]([F:15])([F:16])[F:17])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:6][cH:7]1.[F:18][C:19]([CH2:20][NH:21][C:22](=[O:23])[C:24]1([CH2:37][CH2:38][CH2:39][CH2:40][Br:41])[c:25]2[cH:26][cH:27][cH:28][cH:29][c:30]2-[c:31]2[cH:32][cH:33][cH:34][cH:35][c:36]21)([F:42])[F:43]>>[Cl:1][c:2]1[c:3]([C:14]([F:15])([F:16])[F:17])[cH:4][c:5]([N:8]2[CH2:9][CH2:10][N:11]([CH2:40][CH2:39][CH2:38][CH2:37][C:24]3([C:22]([NH:21][CH2:20][C:19]([F:18])([F:42])[F:43])=[O:23])[c:25]4[cH:26][cH:27][cH:28][cH:29][c:30]4-[c:31]4[cH:32][cH:33][cH:34][cH:35][c:36]43)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 27781371-(4-Chloro-3-(trifluoromethyl)phenyl)piperazineHCID 105264379-(4-Bromobutyl)-N-(2,2,2-trifluoroethyl)-9H-fluorene-9-carboxamide

Product 1

HCID 226401109-{4-[4-(4-Chloro-3-trifluoromethyl-phenyl)-piperazin-1-yl]-butyl}-9H-fluorene-9-carboxylic acid-(2,2,2-trifluoroethyl)-amide

Sources & evidence

ORD record
ord-6ec36fe88353478c94e57972c49178ce
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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