Methyl iodide → HCID 67375715, compound

Participants

Reaction Steps

4.25 g of 4-cyanofluorene, 2.6 g of sodium hydride (60% in oil) and 50 ml of NMP are stirred at room temperature for 2 hours. Then, 9.3 g of methyl iodide are added to the reaction mixture drop-wisely and stirred for an additional 2 hours at room temperature. The reaction mixture is poured into 100 ml of water and filtered. The crude product is purified by column chromatography, giving 3.9 g (80%) of 4-cyano-9,9-dimethylfluorene.

Provenance & Evidence