Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 1-[4-chloro-6-(4-methyl-1-piperazinyl)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide | HCID 86644314 | — |
| Product | HCID 178480804 | HCID 178480804 | — |
Reaction Steps
To ⅕ of the suspension prepared in step b (0.542 mmol, 1.00 equiv) was added 6 N NaOH. The resulting mixture was heated to 80° C. for 1 h. The final solution was directly purified by reverse-phase HPLC (Sunfire, 20-40% CH3CN, H2O, 0.1% TFA, 12 min) to afford 21.2 mg of the title compound. MS (ES+): m/e 480.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08008483B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-795a91dce1f349ed88dac7444f774f02 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
