Sodium Methoxide → 1-[4-(Methoxy)-6-(4-methyl-1-piperazinyl)-1,3,5-triazin-2-yl]-N-{[2-(trifluoromethyl)phenyl]methyl}-4-piperidinecarboxamide

Participants

Reaction Conditions

Reaction Steps

⅕ of the suspension prepared in step b of Example 20 (0.542 mmol, 1.00 equiv) was concentrated under reduced pressure. Then, sodium methoxide (1.24 mL of 25 wt % solution in MeOH, 5.42 mmol, 10.0 equiv) was added. The resulting mixture was heated to 80° C. for 1 h. The final solution was purified by reverse-phase HPLC (Sunfire, 20-40% CH3CN, H2O, 0.1% TFA, 12 min) to afford 12.2 mg of the title compound. MS (ES+): m/e 493.8 [M+H]+.

Provenance & Evidence