Methylamine → 4,6-dichloro-N-methyl-1,3,5-triazin-2-amine

Participants

Reaction Conditions

Reaction Steps

To a suspension of cyanuric chloride (3.00 g, 16.3 mmol, 1.00 equiv) in 1:1 CH3CN:H2O (27 mL) at 0° C. was added NH2Me (2.0 M solution in THF, 8.13 mL, 16.3 mmol, 1.00 equiv). The mixture was treated with 1 N NaOH to maintain a pH of 9-10, and the resulting suspension was stirred for 5 min at 0° C. This material was used in the next step without workup or purification. MS (ES+): m/e 178.9 [M+H]+.

Provenance & Evidence