4-Piperidinecarboxylic acid → 1-[4-Chloro-6-(methylamino)-1,3,5-triazin-2-yl]-4-piperidinecarboxylic acid

Participants

Reaction Conditions

Reaction Steps

4-Piperidinecarboxylic acid (2.10 g, 16.3 mmol, 1.00 equiv) was added to the suspension prepared in step a. The resulting mixture was heated to 40° C. and treated with 1 N NaOH to maintain a pH of 9-10. The reaction mixture was stirred for 2 h at the same temperature and then used immediately in the next step without workup or purification. MS (ES+): m/e 428.9 [M+H]+.

Provenance & Evidence