2,4-Dichlorobenzylamine → HCID 25262079, compound

Participants

Reaction Steps

To a solution of 1-[4-(methylamino)-6-(4-methyl-1-piperazinyl)-1,3,5-triazin-2-yl]-4-piperidinecarboxylic acid (84 mg, 0.25 mmol, 1.0 equiv), [(2,4-dichlorophenyl)methyl]amine (44 μL, 0.31 mmol, 1.3 equiv), and diisopropylethylamine (DIEA, 70 μL, 0.38 mmol, 1.5 equiv) in DMF (1.6 mL) was added BOP (166 mg, 0.38 mmol, 1.5 equiv). The reaction mixture was stirred overnight at room temperature. The resulting solution was filtered and purified using reverse-phase HPLC (Sunfire, 10-45% CH3CN/H2O, 0.1% TFA, 12 min) to afford 28 mg (23%) of the title compound. MS (ES+): m/e 493.1 [M]+.

Provenance & Evidence