HCID 59822343, compound → HCID 67372578, compound

Participants

Reaction Steps

2′-Methyl-5′-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-carboxylic acid ethyl ester (0.89 g) in THF (10 ml) and 0.5M NaOH (15 m) was heated to 100° C. for 3 hours then cooled to room temperature. THF was evaporated and the residue extracted with dichloromethane. The aqueous layer was acidified to pH 1 and a grey solid precipitated which was collected by filtration and dried (0.74 g).

Provenance & Evidence