HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → [2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Benzenamine, 4-(4-morpholinyl)- | HCID 75655 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 4'-tert-Butoxycarbonylamino-2'-methyl-biphenyl-3-carboxylic acid | HCID 59822363 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | [2-Methyl-3'-(4-morpholin-4-yl-phenylcarbamoyl)-biphenyl-4-yl]-carbamic acid tert-butyl ester | HCID 59822359 | — |
Reaction Steps
A mixture of 4′-tert-butoxycarbonylamino-2′-methyl-biphenyl-3-carboxylic acid (436 mg), 4-morpholin-4-yl aniline (238 mg), triethylamine (0.55 ml) and O-benzotriazol-1-yl-N,N,N′,N′-tetramethyluronium hexafluorophosphate (757 mg) in dry DMF (1 ml) was stirred at 20 C for 18 h. Water (50 ml) was then added and the resulting colourless precipitate was collected by filtration and dried (680 mg)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-b2ec8780220443e68cdffdbc65bcc0e2 |
| Source note | uspto-grants-2011_08 |