Cesium carbonate → HCID 16221823, compound

Participants

Reaction Steps

A mixture of 4-(1,1-dioxo-1lambda*6*-thiomorpholin-4-ylmethyl) -N-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-benzamide (70 mg), cyclopropanecarboxylic acid (3-bromo-4-methyl-phenyl)-amide (38 mg) in DME (4 ml) and water (1.5 ml) containing cesium carbonate (50 mg) and tetrakis(triphenylphosphine) palladium (0) (10 mg) was heated to reflux for 18 h. The cooled mixture was then partitioned between water and ethyl acetate. The dried extracts were evaporated and the residue purified on silica gel. Elution with 0-30% DCM:EtOH:NH3; 20:8:1 in DCM gave the title compound as a tan solid (6 mg)

Provenance & Evidence