HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 2'-Methyl-5'-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2'-Methyl-5'-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester | HCID 59822340 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2'-Methyl-5'-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid | HCID 59822395 | 76.8% |
Reaction Steps
2′-Methyl-5′-[(morpholine-4-carbonyl)-amino]-biphenyl-4-carboxylic acid ethyl ester (416 mg) was stirred in ethanol (15 ml) and 1M sodium hydroxide (4 ml) at 20 C for 18 h. The mixture was then acidified and extracted with dichloromethane. The dried extracts were then evaporated giving the title compound as a beige solid (295 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08008303B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-3b8a6f3da2ad47c99f596fb5e23a4ec9 |
| Source note | uspto-grants-2011_08 |