反应详情

A mixture of (3-bromo-4-trifluoromethoxy-phenyl)-carbamic acid tert-butyl ester (250 mg), 4-ethoxycarbonyl-phenyl boronic acid (136 mg), cesium carbonate (228 mg) and tetrakis(triphenylphosphine)palladium0 (catalytic quantity), in 1:2 aqueous DME (15 ml) was heated to reflux for 18 h. The mixture was then cooled and partitioned between water and ethyl acetate. The dried extracts were evaporated and the residue purified on silica gel. Elution with 5-40% ethyl acetate:petrol gave a pale yellow solid (217 mg)

1. temperatureto reflux for 18 h
2. temperatureThe mixture was then cooled
3. custompartitioned between water and ethyl acetate
4. customThe dried extracts were evaporated
5. customthe residue purified on silica gel
6. washElution with 5-40% ethyl acetate