5'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid ethyl ester → 5'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid

HRID 1678477Notes

Reaction equation

HRID 1678477 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])=[O:20])[CH:15]=[CH:14][C:13]=2[O:26][C:27]([F:30])([F:29])[F:28])=[CH:8][CH:7]=1)=[O:5])C>C(O)C.[OH-].[Na+]>[C:22]([O:21][C:19]([NH:18][C:16]1[CH:15]=[CH:14][C:13]([O:26][C:27]([F:28])([F:29])[F:30])=[C:12]([C:9]2[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=2)[CH:17]=1)=[O:20])([CH3:25])([CH3:23])[CH3:24]

Participants

4

Reactant 1

HCID 598223825'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid ethyl ester

Product 1

HCID 598223415'-tert-Butoxycarbonylamino-2'-trifluoromethoxy-biphenyl-4-carboxylic acid

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

5′-tert-Butoxycarbonylamino-2′-trifluoromethoxy-biphenyl-4-carboxylic acid ethyl ester (200 mg) in ethanol (7 ml) and 2M sodium hydroxide (4 ml) was stirred at 20 C for 18 h. The ethanol was then evaporated and the residue acidified. The solid thus formed was collected by filtration and dried (128 mg)

Workup

  1. customThe ethanol was then evaporated
  2. customThe solid thus formed
  3. filtrationwas collected by filtration
  4. customdried (128 mg)

Sources & evidence

ORD record
ord-c2647c23e19b4de98b0d5634155c1ed1
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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