HCID 59822357, compound → HCID 59822387, compound

HRID 1678483Notes

Reaction equation

HRID 1678483 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[CH:10][C:9]([C:12]2[CH:17]=[C:16]([NH:18][C:19]([CH:21]3[CH2:23][CH2:22]3)=[O:20])[CH:15]=[CH:14][C:13]=2[O:24][CH3:25])=[CH:8][CH:7]=1)=[O:5])C>C(O)C.[OH-].[Na+]>[CH:21]1([C:19]([NH:18][C:16]2[CH:15]=[CH:14][C:13]([O:24][CH3:25])=[C:12]([C:9]3[CH:10]=[CH:11][C:6]([C:4]([OH:5])=[O:3])=[CH:7][CH:8]=3)[CH:17]=2)=[O:20])[CH2:23][CH2:22]1

Participants

4

Reactant 1

HCID 59822357HCID 59822357, compound

Product 1

HCID 59822387HCID 59822387, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

A mixture of 5′-(cyclopropanecarbonyl-amino)-2′-methoxy-biphenyl-4-carboxylic acid ethyl ester (88 mg) in ethanol (7 ml) and 2M sodium hydroxide (4 ml) was stirred at 20 C for 18 h. The ethanol was then evaporated and the residue acidified. The solid thus formed was collected by filtration and dried (55 mg)

Workup

  1. customThe ethanol was then evaporated
  2. customThe solid thus formed
  3. filtrationwas collected by filtration
  4. customdried (55 mg)

Sources & evidence

ORD record
ord-0661766366ce41baa0a23ffbd0d1b3ba
Source dataset
uspto-grants-2011_08
Patent number
US08008303B2

Reaction notes

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